Drosophila melanogaster is a species of fly (the taxonomic order Diptera) in the family Drosophilidae. Starting with Charles W. Woodworths proposal of the use of this species as a model organism, D. melanogaster continues to be widely used for biological research in genetics, physiology, microbial pathogenesis, and life history evolution. As of 2017, six Nobel prizes had been awarded for research using Drosophila.

Host Genome

Chromosome
Genome ID Level BUSCO Assessment
GCA_000001215.4 Chromosome
C:99.9%[S:99.3%,D:0.6%],F:0.0%,M:0.1%,n:1367

Related Symbionts

63 records

Symbiont records associated with Drosophila melanogaster

Classification Function Function Tags Reference
Bacteria

L. monocytogenes infection disrupts host energy metabolism by depleting energy stores (triglycerides and glycogen) and reducing metabolic pathway act…

Immune priming
Wolbachia

Pseudomonadota

Bacteria

be reported both to extend and shorten longevity. The main molecular pathways underlying the lifespan-modulating effects of Wolbachia remain unclear,…

Acetobacter

Pseudomonadota

Bacteria

The bacterial cells may thus be able to ameliorate the pH of the acidic region, by the release of weak bases.Additionally, the bacteria have a comple…

Fertility
Lactobacillus

Bacillota

Bacteria

The bacterial cells may thus be able to ameliorate the pH of the acidic region, by the release of weak bases.Additionally, the bacteria have a comple…

Fertility
Wolbachia

Pseudomonadota

Bacteria

Wolbachia infection affects differential gene expression in Drosophila testis.Genes involved in carbohydrate metabolism, lysosomal degradation, prote…

Immune priming
Wolbachia

Pseudomonadota

Bacteria

Upregulate expression of Pale and Ddc, mediates the expression of dopamine related genes, increase total sleep time in both male and female Drosophil…

Wolbachia

Pseudomonadota

Bacteria

Wolbachia infection changes the expression of several genes putatively associated with spermatogenesis including JH induced protein-26 and Mst84Db, o…

Immune priming
Acetobacter

Pseudomonadota

Bacteria

The exist of Acetobacter had a balancing effect on food ingestion when carbohydrate levels were high in the warmer months, stabilizing fitness compon…

Nutrient provision
Wolbachia

Pseudomonadota

Bacteria

A specific strain of Wolbachia was observed to reduce the initiation of aggressive encounters in Drosophila males, which may achieved by influencing …

Wolbachia popcorn

Pseudomonadota

Bacteria

begins massive proliferation in the adult, causing widespread degeneration of tissues, including brain, retina, and muscle, culminating in early death

Bacteria

S. poulsonii protects its host against parasitoid wasps and nematodes by the action of toxins from the family of Ribosome Inactivating Proteins

Wolbachia

Pseudomonadota

Bacteria

enhance nanos expression via the bacterial TomO protein in order to fuel germ stem cell maintenance in infected Drosophila females

Fertility
Bacteria

Spiroplasma coopts the yolk transport and uptake machinery to colonize the germ line and ensure efficient vertical transmission

Wolbachia pipientis

Pseudomonadota

Bacteria

increases the recombination rate observed across two genomic intervals and increases the efficacy of natural selection in hosts

Bacteria

supporting the hypothesis that competition for host lipids underlies S. poulsonii-mediated protection against parasitoid wasps

Natural enemy resistance
Wolbachia

Pseudomonadota

Bacteria

Wolbachia can protect insects against the La Jolla virus (LJV; Iflaviridae) and Newfield virus (NFV; Permutotetraviridae)

Pathogen interaction
Spiroplasma

Mycoplasmatota

Bacteria

in old flies, display neurodegenerative phenotypes and have a reduced life span compared to uninfected controls

Growth and Development
Spiroplasma

Mycoplasmatota

Bacteria

the presence of Wolbachia and Spiroplasma in D. melanogaster up-regulated certain immune-related genes

Immune priming
Wolbachia

Pseudomonadota

Bacteria

Wolbach regulates the host's transcriptional response to viral infection and affects viral replication

Pathogen interaction
Wolbachia

Pseudomonadota

Bacteria

the presence of Wolbachia and Spiroplasma in D. melanogaster up-regulated certain immune-related genes

Immune priming
Wolbachia pipientis

Pseudomonadota

Bacteria

Wolbachia influence octopamine metabolism in the Drosophila females, which is by the symbiont genotype

Acetobacter malorum

Pseudomonadota

Bacteria

resulted in the development of larger ovaries and in increased egg numbers in an oviposition assay.

Fertility
Fungi

resulted in the development of larger ovaries and in increased egg numbers in an oviposition assay.

Fertility
Bacteria

manipulates the reproduction of its host by killing its male progeny at the embryonic stage

Reproductive manipulation
Wolbachia

Pseudomonadota

Bacteria

Wolbachia strain wMel changes the composition of gut commensal bacteria in the fruit fly

Bacteria

L. plantarum increases its growth-promotion ability by adapting to Drosophila diet

Growth and Development
Bacteria

L. plantarum increases its growth-promotion ability by adapting to Drosophila diet

Growth and Development
Bacteria

L. plantarum increases its growth-promotion ability by adapting to Drosophila diet

Growth and Development
Bacteria

L. plantarum increases its growth-promotion ability by adapting to Drosophila diet

Growth and Development
Bacteria

L. plantarum increases its growth-promotion ability by adapting to Drosophila diet

Growth and Development
Bacteria

L. plantarum increases its growth-promotion ability by adapting to Drosophila diet

Growth and Development
Bacteria

L. plantarum increases its growth-promotion ability by adapting to Drosophila diet

Growth and Development
Bacteria

L. plantarum increases its growth-promotion ability by adapting to Drosophila diet

Growth and Development
Bacteria

L. plantarum increases its growth-promotion ability by adapting to Drosophila diet

Growth and Development
Bacteria

L. plantarum increases its growth-promotion ability by adapting to Drosophila diet

Growth and Development
Bacteria

L. plantarum increases its growth-promotion ability by adapting to Drosophila diet

Growth and Development
Bacteria

L. plantarum increases its growth-promotion ability by adapting to Drosophila diet

Growth and Development
Bacteria

L. plantarum increases its growth-promotion ability by adapting to Drosophila diet

Growth and Development
Bacteria

L. plantarum increases its growth-promotion ability by adapting to Drosophila diet

Growth and Development
Bacteria

L. plantarum increases its growth-promotion ability by adapting to Drosophila diet

Growth and Development
Bacteria

L. plantarum increases its growth-promotion ability by adapting to Drosophila diet

Growth and Development
Bacteria

an S. poulsonii protein, designated Spaid, whose expression induces male killing

Reproductive manipulation
Bacteria

an S. poulsonii protein, designated Spaid, whose expression induces male killing

Reproductive manipulation
Wolbachia wMelPop

Pseudomonadota

Bacteria

The virulent wMelPop can improve the learning and memory capacity of Drosophila.

Fertility Growth and Development
Fungi

mediate Drosophila melanogaster attraction, oviposition and development

Growth and Development
Bacteria

It has the potential to reduce IMI-induced susceptibility to infection.

Nutrient provision
Bacteria

Surface bacteria can defend flies against fungal parasitic infections

Antimicrobials
Bacteria

may be beneficial in reducing in vivo Chlorpyrifos (CP) toxicity

Pesticide metabolization
Bacteria

produces toxin complex (Tc) toxins as major virulence factors

Chemical biosynthesis
Wolbachia pipientis

Pseudomonadota

Bacteria

Increasing Heat Stress Resistance of Drosophila melanogaster

Bacteria

gut microbiota of a host for nutritional needs and survival

Nutrient provision
Bacteria

gut microbiota of a host for nutritional needs and survival

Nutrient provision
Bacteria

could effectively inhibit fungal spore germinations

Antimicrobials
Bacteria

Increase chemotaxis response to odorants

Bacteria

Reduce memory of olfactory appetitive

Bacteria

male-killing Spiroplasma bacterium

Reproductive manipulation
Bacteria

male-killing Spiroplasma bacterium

Reproductive manipulation
Bacteria

Decrease olfactory discrimination

Bacteria

-

Bacteria

-

Bacteria

-

Bacteria

-

Streptomyces

Actinomycetota

Bacteria

-

Back to Table

Metagenome Information

0 records

Metagenome sequencing data associated with Drosophila melanogaster

Run Platform Location Date BioProject

No metagenomes found

No metagenome records associated with this host species.

Amplicon Information

63 records

Amplicon sequencing data associated with Drosophila melanogaster

Run Classification Platform Location Environment
SRR5682895

AMPLICON

16S
-
Australia
-
SRR5682894

AMPLICON

16S
-
Australia
-
DRR358050

AMPLICON

16S
-
uncalculated

missing

missing

missing

DRR358051

AMPLICON

16S
-
uncalculated

missing

missing

missing

SRR5682875

AMPLICON

16S
-
Australia
-
SRR5682876

AMPLICON

16S
-
Australia
-
SRR5682877

AMPLICON

16S
-
Australia
-
SRR5682878

AMPLICON

16S
-
Australia
-
SRR5682879

AMPLICON

16S
-
Australia
-
SRR5682880

AMPLICON

16S
-
Australia
-
SRR5682881

AMPLICON

16S
-
Australia
-
SRR5682882

AMPLICON

16S
-
Australia
-
SRR5682883

AMPLICON

16S
-
Australia
-
SRR5682884

AMPLICON

16S
-
Australia
-
SRR5682885

AMPLICON

16S
-
Australia
-
SRR5682886

AMPLICON

16S
-
Australia
-
SRR5682887

AMPLICON

16S
-
Australia
-
SRR5682888

AMPLICON

16S
-
Australia
-
SRR5682889

AMPLICON

16S
-
Australia
-
SRR5682890

AMPLICON

16S
-
Australia
-
SRR5682891

AMPLICON

16S
-
Australia
-
SRR5682892

AMPLICON

16S
-
Australia
-
SRR5682893

AMPLICON

16S
-
Australia
-
SRR15332035

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Six days post eclosion

SRR15332017

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Ten days post eclosion

SRR15331991

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Six days post eclosion

SRR15331993

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Six days post eclosion

SRR15331995

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Two days post eclosion

SRR15331997

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Two days post eclosion

SRR15331999

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Six days post eclosion

SRR15332001

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Six days post eclosion

SRR15332003

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Two days post eclosion

SRR15332005

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Two days post eclosion

SRR15332007

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Two days post eclosion

SRR15332009

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Two days post eclosion

SRR15332011

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Two days post eclosion

SRR15332013

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Ten days post eclosion

SRR15332015

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Ten days post eclosion

SRR15331989

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Six days post eclosion

SRR15332019

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Ten days post eclosion

SRR15332021

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Two days post eclosion

SRR15332023

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Ten days post eclosion

SRR15332025

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Ten days post eclosion

SRR15332027

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Ten days post eclosion

SRR15332029

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Six days post eclosion

SRR15332031

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Six days post eclosion

SRR15332033

AMPLICON

16S
-
China

31.2 N 121.4 E

Fruit fly body surface

Six days post eclosion

SRR14350755

AMPLICON

16S
-
Canada

68.87 N 93.13 W

-
SRR14350756

AMPLICON

16S
-
Canada

68.87 N 93.13 W

-
SRR14350745

AMPLICON

16S
-
Canada

68.87 N 93.13 W

-
SRR14350746

AMPLICON

16S
-
Canada

68.87 N 93.13 W

-
SRR14350747

AMPLICON

16S
-
Canada

68.87 N 93.13 W

-
SRR14350748

AMPLICON

16S
-
Canada

68.87 N 93.13 W

-
SRR14350749

AMPLICON

16S
-
Canada

68.87 N 93.13 W

-
SRR14350750

AMPLICON

16S
-
Canada

68.87 N 93.13 W

-
SRR14350751

AMPLICON

16S
-
Canada

68.87 N 93.13 W

-
SRR14350752

AMPLICON

16S
-
Canada

68.87 N 93.13 W

-
SRR14350753

AMPLICON

16S
-
Canada

68.87 N 93.13 W

-
SRR14350754

AMPLICON

16S
-
Canada

68.87 N 93.13 W

-
SRR13089526

AMPLICON

16S
-
China

30.3 N 120.2 E

-
SRR13089525

AMPLICON

16S
-
China

30.3 N 120.2 E

-
SRR9587990

AMPLICON

16S
-
China

30.3 N 120.2 E

-
SRR9587989

AMPLICON

16S
-
China

30.3 N 120.2 E

-

Related Articles

39 records

Research articles related to Drosophila melanogaster

Title Authors Journal Year DOI
Hu, JC; Bi, R; Luo, YX ... Jia, YC; Mao, CX
INSECT SCIENCE
2024
10.1111/1744-7917.13370
Chen, MY; Li, D; Wang, ZN ... Zhang, S; Wang, YF
Animal Behaviour
2024
10.1016/j.anbehav.2024.03.016
Hong, S; Sun, YL; Chen, HM; Wang, CS
ISME JOURNAL
2023
10.1038/s41396-022-01323-7
Bruner-Montero, G; Jiggins, FM
SCIENTIFIC REPORTS
2023
10.1038/s41598-023-35726-z
Korenskaia, AE; Shishkina, OD; Klimenko, AI ... Vasiliev, GV; Gruntenko, NE
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2022
10.3390/ijms232416212
Hong, S; Sun, YL; Sun, DP; Wang, CS
iScience
2022
10.1016/j.isci.2022.104408
Masson, F; Rommelaere, S; Schüpfer, F; Boquete, JP; Lemaitre, B
Proceedings of the National Academy of Sciences
2022
10.1073/pnas.2208461119
Xu, Y; Viswanatha, R; Sitsel, O ... Perrimon, N; Dong, M
NATURE
2022
10.1038/s41586-022-05250-7
Maritan, E; Gallo, M; Srutkova, D ... Schwarzer, M; Martino, ME
BMC Biology
2022
10.1186/s12915-022-01477-y
Zhou, SC; Lu, YQ; Chen, JN ... Chen, XX; Huang, JH
ISME JOURNAL
2022
10.1038/s41396-022-01301-z
Dou, WH; Miao, YH; Xiao, JH; Huang, DW
MICROBIAL ECOLOGY
2021
10.1007/s00248-021-01703-0
Cai, Xiaoyu Tracy; Li, Hongjie; Borch Jensen, Martin ... Haghighi, Pejmun; Jasper, Heinrich
Nature
2021
10.1038/s41586-021-03756-0
Silva, V; Palacios-Muñoz, A; Okray, Z ... Douglas, AE; Ewer, J
JOURNAL OF EXPERIMENTAL BIOLOGY
2021
10.1242/jeb.233619
Davies, LR; Loeschcke, V; Schou, MF; Schramm, A; Kristensen, TN
SCIENTIFIC REPORTS
2021
10.1038/s41598-021-98119-0
Lindsey, ARI; Bhattacharya, T; Hardy, RW; Newton, ILG
MBIO
2021
10.1128/mbio.03472-20
Masson, F; Schüpfer, F; Jollivet, C; Lemaitre, B
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
2020
10.1128/AEM.00835-20
Garcia-Arraez, MG; Masson, F; Escobar, JCP; Lemaitre, B
BMC MICROBIOLOGY
2019
10.1186/s12866-019-1410-1
Slankster, Eryn; Lee, Cammie; Hess, Kristen M.; Odell, Seth; Mathew, Dennis
Bios
2019
10.1893/0005-3155-90.4.227
Adonyeva, NV; Burdina, EV; Bykov, RA; Gruntenko, NE; Rauschenbach, IY
RUSSIAN JOURNAL OF GENETICS
2019
10.1134/S1022795419050028
Qiao, HL; Keesey, IW; Hansson, BS; Knaden, M
JOURNAL OF EXPERIMENTAL BIOLOGY
2019
10.1242/jeb.192500
Daisley, BA; Trinder, M; McDowell, TW ... Sumarah, MW; Reid, G
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
2018
10.1128/AEM.02820-17
Yadav, S; Gupta, S; Eleftherianos, I
Insects
2018
10.3390/insects9010017
Martino, ME; Joncour, P; Leenay, R ... Beisel, C; Leulier, F
Cell Host & Microbe
2018
10.1016/j.chom.2018.06.001
Bi, Jie; Sehgal, Amita; Williams, Julie A.; Wang, Yu-Feng
Journal of Insect Physiology
2018
10.1016/j.jinsphys.2018.02.011
Harumoto, T; Lemaitre, B
Nature
2018
10.1038/s41586-018-0086-2
Ote, M; Yamamoto, D
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
2018
10.1002/arch.21471
Simhadri, RK; Fast, EM; Guo, R ... Slatko, BE; Frydman, HM
mSphere
2017
10.1128/mSphere.00287-17
Daisley, BA; Trinder, M; McDowell, TW ... Sumarah, MW; Reid, G
SCIENTIFIC REPORTS
2017
10.1038/s41598-017-02806-w
Paredes, JC; Herren, JK; Schüpfer, F; Lemaitre, B
mBio
2016
10.1128/mbio.01006-16
Maistrenko, OM; Serga, SV; Vaiserman, AM; Kozeretska, IA
Biogerontology
2016
10.1007/s10522-016-9653-9
Shokal, U; Yadav, S; Atri, J ... Jaenike, J; Eleftherianos, I
BMC MICROBIOLOGY
2016
10.1186/s12866-016-0634-6
Overend, G; Luo, Y; Henderson, L ... Davies, SA; Dow, JAT
SCIENTIFIC REPORTS
2016
10.1038/srep27242
Rohrscheib, CE; Bondy, E; Josh, P ... Weible, MW; Brownlie, JC
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
2015
10.1128/AEM.00573-15
Paredes, JC; Herren, JK; Schüpfer, F ... Lemaitre, B; Béven, L
MBIO
2015
10.1128/mbio.02437-14
Herren, JK; Paredes, JC; Schüpfer, F; Lemaitre, B
MBIO
2013
10.1128/mbio.00532-12
Chambers, Moria C.; Song, Kyung Han; Schneider, David S.
PLoS ONE
2012
10.1371/journal.pone.0050679
Becher, Paul G.; Flick, Gerhard; Rozpędowska, Elżbieta ... Witzgall, Peter; Bengtsson, Marie
Functional Ecology
2012
10.1111/j.1365-2435.2012.02006.x
Zheng, Y; Wang, JL; Liu, C ... Walker, T; Wang, YF
BMC GENOMICS
2011
10.1186/1471-2164-12-595
Min, KT; Benzer, S
Proceedings of the National Academy of Sciences of the United States of America
1997
10.1073/pnas.94.20.10792

Core Microbiome Composition

Core microbiome composition is derived from available metagenomic and amplicon sequencing data, calculated based on the relative abundance and coverage of symbionts across different samples. The representativeness of this analysis may vary depending on the number of available samples and should be considered as a reference guide. See calculation details in Help documentation

Interactive Taxonomy Visualization