SRR19201377 - Xylomedes rufocoronata

Basic Information

Run: SRR19201377

Assay Type: WGS

Bioproject: PRJNA836854

Biosample: SAMN28175370

Bytes: 2678740051

Center Name: JOHANNES GUTENBERG-UNIVERSITY MAINZ

Sequencing Information

Instrument: Illumina HiSeq 3000

Library Layout: PAIRED

Library Selection: RANDOM

Platform: ILLUMINA

Geographic Information

Country: United Arab Emirates

Continent: Asia

Location Name: United Arab Emirates: Emirate of Sharjah

Latitude/Longitude: -

Sample Information

Host: Xylomedes rufocoronata

Isolation: beetle abdomen

Biosample Model: Metagenome or environmental

Collection Date: 2006-03-22

Taxonomic Classification

Potential Symbionts

Based on our current records database, this section aims to identify potential functional symbionts in this metagenome sample, with scoring based on:

  • Relative abundance in sample
  • Species-level matches with known symbionts
  • Host insect order matches
  • Functional record completeness

Note: Showing top 3 highest scoring records for each species/genus

Symbiont Name Record Host Species Function Abundance
Score
Wolbachia
RISB1452
Octodonta nipae
Order: Coleoptera
Wolbachia harbored dominantly in a female than the male adult, while, no significant differences were observed between male and female body parts and tissues
25.95%
39.1
Wolbachia
RISB2107
Sitophilus zeamais
Order: Coleoptera
Wolbachia directly favored weevil fertility and exhibited only mild indirect effects, usually enhancing the SZPE effect
25.95%
38.3
Wolbachia
RISB1282
Ips sp.
Order: Coleoptera
inducing cytoplasmic incompatibility, resulting in reproductive distortions and hence
25.95%
37.7
Pseudomonas sp. CIP-10
RISB1622
Dendroctonus valens
Order: Coleoptera
volatiles from predominant bacteria regulate the consumption sequence of carbon sources d-pinitol and d-glucose in the fungal symbiont Leptographium procerum, and appear to alleviate the antagonistic effect from the fungus against RTB larvae
1.18%
21.0
Escherichia coli
RISB0128
Tribolium castaneum
Order: Coleoptera
may produce 4,8-dimethyldecanal (DMD) production that is strongly associated with attraction to females and host pheromone communication
2.62%
20.3
Acinetobacter sp. TAC-1
RISB0730
Curculio chinensis
Order: Coleoptera
Acinetobacter sp. in C. chinensis enriched after treating with saponin, and when incubating bacteria with saponin for 72 h, saponin content significantly decreased from 4.054 to 1.867 mg/mL (by 16S rRNA metagenome sequencing and HPLC)
0.15%
19.8
Pseudomonas sp. CIP-10
RISB2224
Leptinotarsa decemlineata
Order: Coleoptera
Colorado potato beetle (Leptinotarsa decemlineata) larvae exploit bacteria in their oral secretions to suppress antiherbivore defenses in tomato (Solanum lycopersicum)
1.18%
19.5
Lactococcus lactis
RISB0967
Oulema melanopus
Order: Coleoptera
contribute to the decomposition of complex carbohydrates, fatty acids, or polysaccharides in the insect gut. It might also contribute to the improvement of nutrient availability.
0.36%
18.9
Sphingobacterium sp. ML3W
RISB2227
Leptinotarsa decemlineata
Order: Coleoptera
Colorado potato beetle (Leptinotarsa decemlineata) larvae exploit bacteria in their oral secretions to suppress antiherbivore defenses in tomato (Solanum lycopersicum)
0.04%
18.4
Bacillus cereus
RISB1056
Oryctes rhinoceros
Order: Coleoptera
provide symbiotic digestive functions to Oryctes
2.13%
18.1
Bacillus cereus
RISB1778
Lissorhoptrus oryzophilus
Order: Coleoptera
might be promising paratransgenesis candidates
2.13%
18.1
Klebsiella pneumoniae
RISB1153
Tenebrio molitor
Order: Coleoptera
degrading plastics
2.58%
17.9
Morganella morganii
RISB1867
Costelytra zealandica
Order: Coleoptera
Female beetles were previously shown to use phenol as their sex pheromone produced by symbiotic bacteria in the accessory or colleterial gland
0.09%
17.9
Proteus vulgaris
RISB0001
Leptinotarsa decemlineata
Order: Coleoptera
produces toxic hydrogen cyanide (HCN) and a mandelonitrile-producing cyanoglucoside, amygdalin, which protect the insect from predation
0.07%
17.8
Enterococcus faecalis
RISB0497
Cryptolestes ferrugineus
Order: Coleoptera
bacteria can degrade malathion, pirimiphos-methyl, and deltamethrin and utilize these insecticides as the carbon source in vitro.
0.11%
17.7
Bacillus sp. DTU_2020_1000418_1_SI_GHA_SEK_038
RISB1645
Osphranteria coerulescens
Order: Coleoptera
The isolate has cellulolytic activity and can hydrolyze CMC, avicel, cellulose and sawdust with broad temperature and pH stability
0.06%
17.7
Streptomyces sp. WAC00303
RISB0777
Copris tripartitus
Order: Coleoptera
contribute brood ball hygiene by inhibiting fungal parasites in the environment
1.04%
17.6
Pseudomonas sp. CIP-10
RISB0815
Hypothenemus hampei
Order: Coleoptera
might contribute to caffeine breakdown using the C-15 oxidation pathway
1.18%
17.6
Enterococcus faecalis
RISB2042
Harpalus pensylvanicus
Order: Coleoptera
E. faecalis facilitate seed consumption by H. pensylvanicus, possibly by contributing digestive enzymes to their host
0.11%
17.5
Lactococcus lactis
RISB1430
Rhynchophorus ferrugineus
Order: Coleoptera
promote the development and body mass gain of RPW larvae by improving their nutrition metabolism
0.36%
17.3
Acinetobacter sp. TAC-1
RISB0706
Curculio chinensis
Order: Coleoptera
facilitate the degradation of tea saponin; genome contains 47 genes relating to triterpenoids degradation
0.15%
17.3
Morganella morganii
RISB1548
Costelytra zealandica
Order: Coleoptera
symbionts residing in the colleterial glands produce phenol 1 as the female sex pheromone
0.09%
16.9
Morganella morganii
RISB1868
Costelytra zealandica
Order: Coleoptera
produces phenol as the sex pheromone of the host from tyrosine in the colleterial gland
0.09%
16.8
Streptomyces sp. T12
RISB0777
Copris tripartitus
Order: Coleoptera
contribute brood ball hygiene by inhibiting fungal parasites in the environment
0.23%
16.8
Streptomyces sp. SUK 48
RISB0777
Copris tripartitus
Order: Coleoptera
contribute brood ball hygiene by inhibiting fungal parasites in the environment
0.11%
16.7
Acinetobacter sp. TAC-1
RISB0804
Hypothenemus hampei
Order: Coleoptera
might contribute to caffeine breakdown using the C-11 oxidation pathway
0.15%
16.6
Enterococcus faecalis
RISB0374
Tribolium castaneum
Order: Coleoptera
modulates host phosphine resistance by interfering with the redox system
0.11%
16.6
Staphylococcus epidermidis
RISB1070
Oryctes rhinoceros
Order: Coleoptera
gut microbe
1.33%
16.6
Stenotrophomonas maltophilia
RISB0139
Tenebrio molitor
Order: Coleoptera
correlated with polyvinyl chloride PVC degradation
0.46%
16.5
Lactococcus lactis
RISB1065
Oryctes rhinoceros
Order: Coleoptera
gut microbe
0.36%
15.6
Staphylococcus hominis
RISB1071
Oryctes rhinoceros
Order: Coleoptera
gut microbe
0.07%
15.3
Sphingobium
RISB1837
Dendroctonus valens
Order: Coleoptera
It can trongly degrade naringenin, and pinitol, the main soluble carbohydrate of P. tabuliformis, is retained in L. procerum-infected phloem and facilitate naringenin biodegradation by the microbiotas.
0.04%
14.1
Enterobacter
RISB2221
Leptinotarsa decemlineata
Order: Coleoptera
Colorado potato beetle (Leptinotarsa decemlineata) larvae exploit bacteria in their oral secretions to suppress antiherbivore defenses in tomato (Solanum lycopersicum)
0.11%
13.5
Enterobacter
RISB1051
Leptinotarsa decemlineata
Order: Coleoptera
symbiotic bacteria suppressed plant defenses such as hydrogen peroxide and phenolic compounds accumulation and activity of peroxidases and trypsin inhibitors
0.11%
13.3
Enterobacter
RISB0496
Sitophilus oryzae
Order: Coleoptera
bacteria can degrade malathion, pirimiphos-methyl, and deltamethrin and utilize these insecticides as the carbon source in vitro.
0.11%
12.7
Delftia
RISB0806
Hypothenemus hampei
Order: Coleoptera
might contribute to caffeine breakdown using the C-19 oxidation pathway
1.18%
12.6
Klebsiella pneumoniae
RISB2185
Scirpophaga incertulas
Order: Lepidoptera
The ability of these arthropods to feed on wood, foliage and detritus is likely to involve catalysis by different types of cellulases/hemicellulases that are secreted by gut microbiota to digest the structural and recalcitrant lignocellulosic residues in their foods.
2.58%
12.6
Bacteroides
RISB1183
Oryzaephilus surinamensis
Order: Coleoptera
supplement precursors for the cuticle synthesis and thereby enhance desiccation resistance of its host
0.21%
12.3
Xanthomonas
RISB0498
Xylocopa appendiculata
Order: Hymenoptera
Xanthomonas strain from Japanese carpenter bee is effective PU-degradable bacterium and is able to use polyacryl-based PU as a nutritional source, as well as other types of PS-PU and PE-PU
8.46%
12.2
Escherichia coli
RISB1339
Manduca sexta
Order: Lepidoptera
modulate immunity-related gene expression in the infected F0 larvae, and also in their offspring, triggered immune responses in the infected host associated with shifts in both DNA methylation and histone acetylation
2.62%
11.9
Vibrio
RISB1810
Monochamus galloprovincialis
Order: Coleoptera
Have the ability for degradation of cellulose, proteins and starch
0.52%
11.8
Bradyrhizobium
RISB0135
Coccinella septempunctata
Order: Coleoptera
be commonly found in plant roots and they all have nitrogen fixation abilities
0.18%
11.7
Nostoc
RISB0812
Hypothenemus hampei
Order: Coleoptera
might contribute to caffeine breakdown using the C-18 oxidation pathway
0.07%
11.5
Turicibacter
RISB0451
Odontotaenius disjunctus
Order: Coleoptera
degrading  ellulose and xylan
0.03%
10.6
Aeromonas
RISB1145
Tenebrio molitor
Order: Coleoptera
degrading plastics
0.08%
10.4
Xanthomonas
RISB0217
Xylocopa appendiculata
Order: Hymenoptera
strains biodegraded polyethylene terephthalate PET powder, broke it into its degradation products
8.46%
10.4
Lysinibacillus
RISB1066
Oryctes rhinoceros
Order: Coleoptera
gut microbe
0.17%
10.4
Buchnera aphidicola
RISB0236
Acyrthosiphon pisum
Order: Hemiptera
Buchnera the nutritional endosymbiont of A. pisum is located inside of bacteriocytes and requires aspartate from the aphid host, because it cannot make it de novo. Further Buchnera needs aspartate for the biosynthesis of the essential amino acids lysine and threonine, which the aphid and Buchnera require for survival
0.34%
10.3
Listeria monocytogenes
RISB2308
Drosophila melanogaster
Order: Diptera
L. monocytogenes infection disrupts host energy metabolism by depleting energy stores (triglycerides and glycogen) and reducing metabolic pathway activity (beta-oxidation and glycolysis). The infection affects antioxidant defense by reducing uric acid levels and alters amino acid metabolism. These metabolic changes are accompanied by melanization, potentially linked to decreased tyrosine levels.
0.20%
10.2
Buchnera aphidicola
RISB2485
Macrosiphum euphorbiae
Order: Hemiptera
symbiont expression patterns differ between aphid clones with differing levels of virulence, and are influenced by the aphids' host plant. Potentially, symbionts may contribute to differential adaptation of aphids to host plant resistance
0.34%
10.1
Paenibacillus polymyxa
RISB2195
Termitidae
Order: Blattodea
The ability of these arthropods to feed on wood, foliage and detritus is likely to involve catalysis by different types of cellulases/hemicellulases that are secreted by gut microbiota to digest the structural and recalcitrant lignocellulosic residues in their foods.
0.09%
10.1
Stenotrophomonas maltophilia
RISB1122
Bombyx mori
Order: Lepidoptera
facilitate host resistance against organophosphate insecticides, provides essential amino acids that increase host fitness and allow the larvae to better tolerate the toxic effects of the insecticide.
0.46%
9.5
Clostridium sp. AWRP
RISB2301
Pyrrhocoris apterus
Order: Hemiptera
could play an important role for the insect by degrading complex dietary components, providing nutrient supplementation, or detoxifying noxious chemicals (e.g. cyclopropenoic fatty acids or gossypol) in the diet
0.06%
9.3
Clostridium sp. DL-VIII
RISB2301
Pyrrhocoris apterus
Order: Hemiptera
could play an important role for the insect by degrading complex dietary components, providing nutrient supplementation, or detoxifying noxious chemicals (e.g. cyclopropenoic fatty acids or gossypol) in the diet
0.05%
9.3
Clostridium sp. MB40-C1
RISB2301
Pyrrhocoris apterus
Order: Hemiptera
could play an important role for the insect by degrading complex dietary components, providing nutrient supplementation, or detoxifying noxious chemicals (e.g. cyclopropenoic fatty acids or gossypol) in the diet
0.04%
9.3
Buchnera aphidicola
RISB0685
Acyrthosiphon pisum
Order: Hemiptera
It supplies the host with vitamins and essential amino acids, such as arginine and methionine that aphids cannot synthesize or derive insufficiently from their diet, the phloem sap of plants
0.34%
9.1
Mammaliicoccus sciuri
RISB0075
Bombyx mori
Order: Lepidoptera
could produce a secreted chitinolytic lysozyme (termed Msp1) to damage fungal cell walls,completely inhibit the spore germination of fungal entomopathogens Metarhizium robertsii and Beauveria bassiana
0.08%
9.1
Klebsiella pneumoniae
RISB2459
Bombyx mori
Order: Lepidoptera
degradation of cellulose, xylan, pectin and starch
2.58%
8.6
Blattabacterium cuenoti
RISB0133
Panesthiinae
Order: Blattodea
enables hosts to subsist on a nutrient-poor diet; endosymbiont genome erosions are associated with repeated host transitions to an underground life
0.64%
8.6
Escherichia coli
RISB2120
Galleria mellonella
Order: Lepidoptera
mediate trans-generational immune priming
2.62%
8.4
Candidatus Portiera aleyrodidarum
RISB1193
Bemisia tabaci
Order: Hemiptera
synthesizing essential amino acid (e.g. tryptophan, leucine and L-Isoleucine), Bemisia tabaci provides vital nutritional support for growth, development and reproduction
0.04%
8.4
Spiroplasma sp. BIUS-1
RISB1353
Cephus cinctus
Order: Hymenoptera
The bacterium also encoded biosynthetic pathways for essential vitamins B2, B3, and B9. We identified putative Spiroplasma virulence genes: cardiolipin and chitinase.
0.07%
8.4
Stenotrophomonas maltophilia
RISB1227
Delia antiqua
Order: Diptera
six bacteria protect larvae from infection with the entomopathogen Beauveria bassiana through symbiotic bacterium-derived organic acids
0.46%
8.2
Candidatus Portiera aleyrodidarum
RISB2289
Bemisia tabaci
Order: Hemiptera
encoding the capability to synthetize, or participate in the synthesis of, several amino acids and carotenoids,
0.04%
7.3
Candidatus Portiera aleyrodidarum
RISB1973
Bemisia tabaci
Order: Hemiptera
a primary symbiont, which compensates for the deficient nutritional composition of its food sources
0.04%
7.0
Salmonella enterica
RISB0413
Melanaphis sacchari
Order: Hemiptera
None
1.82%
6.8
Blattabacterium cuenoti
RISB0518
Cryptocercus punctulatus
Order: Blattodea
collaborative arginine biosynthesis
0.64%
6.3
Proteus vulgaris
RISB2460
Bombyx mori
Order: Lepidoptera
degradation of cellulose, xylan, pectin and starch
0.07%
6.1
Lactiplantibacillus plantarum
RISB0674
Drosophila melanogaster
Order: Diptera
could effectively inhibit fungal spore germinations
0.05%
6.1
Blattabacterium cuenoti
RISB0093
Blattella germanica
Order: Blattodea
obligate endosymbiont
0.64%
6.1
Providencia rettgeri
RISB1001
Anastrepha obliqua
Order: Diptera
improve the sexual competitiveness of males
0.16%
6.0
Providencia rettgeri
RISB1169
Bactrocera dorsalis
Order: Diptera
Promote the growth of larvae
0.16%
5.7
Chryseobacterium sp. SG20098
RISB2092
Aedes aegypti
Order: Diptera
axenic larvae cannot develop
0.15%
5.7
Staphylococcus hominis
RISB1881
Aedes aegypti
Order: Diptera
gut microbiome
0.07%
5.4
Candidatus Karelsulcia muelleri
RISB1591
Philaenus spumarius
Order: Hemiptera
None
0.18%
5.2
Providencia rettgeri
RISB1352
Nasonia vitripennis
Order: Hymenoptera
None
0.16%
5.2
Candidatus Erwinia haradaeae
RISB1632
Lachninae
Order: Hemiptera
None
0.09%
5.1
Lactiplantibacillus plantarum
RISB0608
Drosophila melanogaster
Order: Diptera
None
0.05%
5.1
Rickettsia prowazekii
RISB1905
Bemisia tabaci
Order: Hemiptera
None
0.04%
5.0
Treponema
RISB2377
termite
Order: Blattodea
when grown together, two termite-gut Treponema species influence each other's gene expression in a far more comprehensive and nuanced manner than might have been predicted based on the results of previous studies on the respective pure cultures
0.09%
5.0
Apibacter
RISB0603
Apis cerana
Order: Hymenoptera
The acquisition of genes for the degradation of the toxic monosaccharides potentiates Apibacter with the ability to utilize the pollen hydrolysis products, at the same time enabling monosaccharide detoxification for the host
0.03%
4.5
Photorhabdus
RISB2532
Manduca sexta
Order: Lepidoptera
produces a small-molecule antibiotic (E)-1,3-dihydroxy-2-(isopropyl)-5-(2-phenylethenyl)benzene (ST) that also acts as an inhibitor of phenoloxidase (PO) in the insect host Manduca sexta.
0.03%
3.8
Peribacillus
RISB1877
Aedes aegypti
Order: Diptera
gut microbiome
3.33%
3.6
Delftia
RISB0083
Osmia cornifrons
Order: Hymenoptera
be known to exhibit antibiotic activity, suggesting their potential protective role against pathogens
1.18%
3.2
Yersinia
RISB0492
Cimex hemipterus
Order: Hemiptera
the disruption of the abundant Yersinia possibly could be related to the enhanced susceptibility towards the insecticides
0.76%
3.2
Candidatus Blochmanniella
RISB2542
Camponotus
Order: Hymenoptera
Blochmannia provide essential amino acids to its host,Camponotus floridanus, and that it may also play a role in nitrogen recycling via its functional urease
0.03%
3.2
Shewanella
RISB1924
Anopheles gambiae
Order: Diptera
may be related with mediating adaptation to different ecological niches or in shaping specific adult behaviors including mating
0.62%
3.2
Candidatus Blochmanniella
RISB1827
Camponotus floridanus
Order: Hymenoptera
a modulation of immune gene expression which may facilitate tolerance towards the endosymbionts and thus may contribute to their transovarial transmission
0.03%
3.1
Photorhabdus
RISB2573
Manduca sexta
Order: Lepidoptera
the bacteria are symbiotic with entomopathogenic nematodes but become pathogenic on release from the nematode into the insect blood system
0.03%
2.8
Candidatus Blochmanniella
RISB2448
Camponotus floridanus
Order: Hymenoptera
nutritional contribution of the bacteria to host metabolism by production of essential amino acids and urease-mediated nitrogen recycling
0.03%
2.8
Bacteroides
RISB0256
Leptocybe invasa
Order: Hymenoptera
Differences in Male-Killing Rickettsia Bacteria between Lineages of the Invasive Gall-Causing Pest Leptocybe invasa
0.21%
2.5
Bacteroides
RISB0090
Hyphantria cunea
Order: Lepidoptera
enhance the compatibility of invasive pests to new hosts and enable more rapid adaptation to new habitats.
0.21%
2.3
Delftia
RISB1754
Spodoptera frugiperda
Order: Lepidoptera
may influence the metabolization of pesticides in insects
1.18%
2.3
Streptococcus
RISB2625
Galleria mellonella
Order: Lepidoptera
suppress bacteria ingested with food by producing bacteriocin and by releasing a lysozyme like enzyme
0.20%
2.2
Sphingomonas
RISB0420
Aphis gossypii
Order: Hemiptera
Sphingomonas could mediate A. gossypii resistance to imidacloprid by hydroxylation and nitroreduction
0.04%
2.1
Sphingomonas
RISB1307
Aphis gossypii
Order: Hemiptera
have been previously described in associations with phloem-feeding insects, in low abundances
0.04%
1.9
Brevibacterium
RISB0464
Acrida cinerea
Order: Orthoptera
correlated with the hemicellulose digestibility
0.95%
1.9
Streptococcus
RISB2624
Reticulitermes flavipes
Order: Blattodea
can be broken down into substances such as carbon dioxide, ammonia and acetic acid
0.20%
1.8
Brevibacterium
RISB2359
Bombyx mori
Order: Lepidoptera
producing lipase in a gut environment
0.95%
1.7
Sphingomonas
RISB0134
Spodoptera frugiperda
Order: Lepidoptera
provide a protective effect to against chlorantraniliprole stress to S. frugiperda
0.04%
1.7
Streptococcus
RISB2604
Homona magnanima
Order: Lepidoptera
influence the growth of Bacillus thuringiensis in the larvae
0.20%
1.4
Variovorax
RISB2153
Osmia bicornis
Order: Hymenoptera
may be essential to support Osmia larvae in their nutrient uptake
0.03%
1.3
Photorhabdus
RISB0532
Drosophila melanogaster
Order: Diptera
produces toxin complex (Tc) toxins as major virulence factors
0.03%
1.3
Cupriavidus
RISB0694
Alydus tomentosus
Order: Hemiptera
None
1.23%
1.2
Paraclostridium
RISB0028
Sesamia inferens
Order: Lepidoptera
degrade Chlorpyrifos and Chlorantraniliprole in vitro
0.11%
1.2
Lysinibacillus
RISB1416
Psammotermes hypostoma
Order: Blattodea
isolates showed significant cellulolytic activity
0.17%
1.2
Brevibacterium
RISB0897
Myzus persicae
Order: Hemiptera
None
0.95%
1.0
Aeromonas
RISB2456
Bombyx mori
Order: Lepidoptera
able to utilize the CMcellulose and xylan
0.08%
0.9
Yersinia
RISB0407
Anaphes nitens
Order: Hymenoptera
None
0.76%
0.8
Flavobacterium
RISB0659
Melanaphis bambusae
Order: Hemiptera
None
0.71%
0.7
Aeromonas
RISB2086
Aedes aegypti
Order: Diptera
axenic larvae cannot develop
0.08%
0.6
Priestia
RISB0839
Helicoverpa armigera
Order: Lepidoptera
producing amylase
0.19%
0.5
Achromobacter
RISB1869
Aedes aegypti
Order: Diptera
gut microbiome
0.14%
0.4
Sphingobium
RISB1880
Aedes aegypti
Order: Diptera
gut microbiome
0.04%
0.3
Paraburkholderia
RISB0125
Physopelta gutta
Order: Hemiptera
None
0.20%
0.2
Achromobacter
RISB0383
Aphis gossypii
Order: Hemiptera
None
0.14%
0.1
Legionella
RISB1687
Polyplax serrata
Order: Phthiraptera
None
0.11%
0.1
Neisseria
RISB0512
Plutella xylostella
Order: Lepidoptera
None
0.10%
0.1
Treponema
RISB0169
Reticulitermes flaviceps
Order: Blattodea
None
0.09%
0.1
Helicobacter
RISB0662
Melanaphis bambusae
Order: Hemiptera
None
0.09%
0.1
Vagococcus
RISB0042
Aldrichina grahami
Order: Diptera
None
0.08%
0.1
Apibacter
RISB0604
Apis cerana
Order: Hymenoptera
None
0.03%
0.0
Variovorax
RISB1712
Phlebotomus papatasi
Order: Diptera
None
0.03%
0.0

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Run ID File Size
SRR19201377
2.5 GB Download

Raw sequencing files are hosted on NCBI SRA. Click the download button to start downloading directly from NCBI servers.

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